![]() ![]() Acute lesions are characterized by intense pruritus, presence of papules and vesicles on erythematous skin, and are associated with excoriation, erosion and serous exudates. The disease may take an acute, subacute or chronic course. The itch is particularly pronounced at night causing sleep impairment, thus having significant negative impact on the quality of life of both patients and their families (2, 3, 5, 6). Intense itching is common in AD resulting in excoriation, pruritic papules, lichenification and eczematous skin lesions (2, 3, 4). The clinical presentations of AD vary depending on the age and course of the disease the major manifestations include erythema, edema, xerosis, erosions/excoriation, oozing and crusting, and lichenification (1, 4, 5, 6, 7). Approximately 25% of AD patients may develop some form of hand eczema during the life (3). Rarely, the first AD manifestations appear in adulthood (2). In most patients manifestations of AD disappear before the adulthood, while in 25% of patients AD persists throughout life (2). In 60% of patients the first manifestations appear within the first year of life, and in 90% of patients before the age of five. AD is one of the most common skin diseases and it affects approximately 20% of children and 1 - 3% of adults (2). Svetlana POPADIC1, Mirjana GAJIC-VELJIC1, Sonja PRCIC2, Zeljko MIJUSKOVIC3, Dragan JOVANOVIC4, Lidija KANDOLF-SEKULOVIC3, Milos NIKOLIC1ġClinic of Dermatovenereology, Clinical Center of Serbia, Department of Dermatovenereology, School of Medicine, University of Belgrade, Belgrade, SerbiaĢInstitute for Child and Youth Health Care of Vojvodina, Faculty of Medicine, University of Novi Sad, SerbiaģClinic of Skin and Venereal Diseases, Military Medical Academy, Department of Dermatovenereology, School of Medicine,ĤDepartment of Dermatovenereology, Clinic of Skin and Venereal Diseases, Clinical Center Nis, School of Medicine, University of Nis, Nis, SerbiaĬorrespondence: Svetlana Popadic, 616.5-002-08(061.2)Ītopic dermatitis (AD) is a disease that usually presents in the early childhood (1). National Guidelines for the Treatment of Atopic Dermatitis ![]()
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